Diazepam se ne sme primenjivati kao monoterapija u terapiji depresije i anksioznosti udružene sa depresijom, jer kod ove grupe pacijenata može uzrokovati pojavu suicida.

Critical: As a result of possibility of misuse, overdose or other hazardous activities connected to benzodiazepines, it’s critical you take ways to guard yourself and others. A very powerful things you can perform incorporate:

Lek Bensedin rastvor za injekciju/infuziju sadrži propilenglikol i etanol (videti odeljak „Posebna upozorenja i mere opreza pri upotrebi leka” u Sažetku karakteristika leka).

You can find a full listing from the producer's information leaflet equipped with your medicine. The undesirable effects generally strengthen as Your whole body adjusts to The brand new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Codeine is remodeled to morphine during the liver by an enzyme. Morphine would be the substance that produces suffering reduction. Some individuals have a variation of this enzyme which can influence people in other ways. In some individuals, morphine is not really made or generated in very modest portions, and it will not present adequate pain aid.

Having this medication on a regular basis, specially for some time, can cause dependancy. Your prescriber should have discussed just how long you're going to be taking it for and when it is suitable to stop, how to do this properly.

If you will get any facet effects, check with your health care provider or pharmacist. This involves any attainable aspect effects not stated During this leaflet. See section 4

Diazepam se uglavnom metaboliše do farmakološki aktivnih metabolita: N-demetildiazepama, temazepama i oksazepama. Oksidativni metabolizam diazepama posredovan je CYP3A4 i CYP2C19 izoenzimima. more info Oksazepam i temazepam se dalje konjuguju do glukuronske kiseline.

Karbamazepin je poznati induktor CYP3A4 izoenzima i ubrzava metabolizam diazepama u jetri. Ovo može rezultirati trostrukim povećanjem klirensa iz plazme i skraćenjem poluvremena eliminacije diazepama. Smanjeno dejstvo diazepama.

Aditivni efekat terapije lekom Bensedin, rastvor za injekciju/infuziju sa drugim proizvodima koji sadrže etanol i/ili dijetetskim unosom etanola treba uzeti u obzir.

Critical: persons taking opioid medicines, as well as their friends and family, should really be familiar with the potential risk of accidental overdose and know when to seek medical enable. The chance is better if In addition, you consider other medicines which make you're feeling drowsy. Signs you have taken too much medication contain:

Codeine is not recommended in little ones with breathing issues, For the reason that signs and symptoms of morphine toxicity may be even worse in these kids.

Codeine shouldn't be utilized for suffering reduction in little ones and adolescents just after removal in their tonsils or adenoids due to Obstructive Slumber Apnoea Syndrome (snooze disruption as a result of respiratory pauses). They may be at enhanced possibility of significant side effects in the event of morphine toxicity.

Dejstvo se može uočiti odmah nakon započinjanja terapije i može trajati nekoliko dana nakon prestanka terapije zbog dugog poluvremena eliminacije galenika bensedin diazepama.